| NF—KB/mTOR双信号通路的交联及其对肿瘤生物学特性的影响 |
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| 引用本文： | 陈华娇,史道华. NF—KB/mTOR双信号通路的交联及其对肿瘤生物学特性的影响[J]. 中国临床药理学与治疗学, 2013, 0(11): 1315-1320 |
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| 作者姓名： | 陈华娇 史道华 |
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| 作者单位： | 福建省妇幼保健院药剂科,福州350001 |
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| 基金项目： | 福建省自然科学基金资助项目（2012JOl312） |
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| 摘 要： | 肿瘤的发生发展涉及多个细胞信号传导通路，其中核因子-IcB（Nuclearfactor—kappaB，NF—KB）通路和哺乳动物雷帕霉素靶蛋白（Mammali—antargetofrapamycin，mTOR）通路尤为重要，已成为研究肿瘤药物治疗的新靶点。进一步探讨两信号通路间存在的交联（Cross-talk）及其对肿瘤生物学特性的影响，有助于更好地调控肿瘤细胞的恶性行为。
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| 关 键 词： | 肿瘤 NF—IcB mTOR 信号通路 交联 |
Cross-talk between NF-KB and mTOR signaling pathways and its effects on tumor biological characteristics |
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| CHEN Hua-jiao,SHI Dao-hua. Cross-talk between NF-KB and mTOR signaling pathways and its effects on tumor biological characteristics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 0(11): 1315-1320 |
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| Authors: | CHEN Hua-jiao SHI Dao-hua |
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| Affiliation: | Department of Pharmacy , Fujian Provincial Maternity and Children Health Hospital , Fuzhou 350001 , Fujian , China |
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| Abstract: | Tumor development involves mul tiple cell signaling pathways. The most impor tant of them are nuclear factor-kappaB （NF-kB） pathway and mammalian target of rapamycin pathway （mTOR）, which is the new target for cancer treatment of drug therapy. Further ex ploration on the cross-talk between these twosignaling pathways and its effects on tumor bio logical characteristics might be useful to control the malignant behavior of tumor cells. |
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| Keywords: | Tumor NF-kB mTOR Signalingpathway Cross-talk |
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