坎地沙坦对自发性高血压大鼠胰岛素抵抗及血清脂联素的影响

目的：探讨血管紧张素Ⅱ受体拮抗剂坎地沙坦对自发性高血压大鼠（SHR）糖代谢及血清脂联素的影响。方法：SHR大鼠分为两组：高血压组（SHR，n=30）；坎地沙坦组（坎地沙坦，1mg·kg-1.d-1，n=30，灌胃法给药），另设同种系WKY大鼠为对照组，给予同等量安慰剂，12周后分别用生化方法和放射免疫方法测定空腹血糖（FBG）和胰岛素水平（FINS），计算IR指数（HOMA—IR），用生化方法进行口服葡萄糖耐量试验（OGTT），ELlSA分析法测定血清脂联素水平。结果：空腹血糖高血压组和对照组大鼠差异无统计学意义（P〉0．05）；空腹胰岛素水平和HOMA—IR与高血压组大鼠相比，对照组和坎地沙坦组要明显降低（P〈0．05）；OGTT结果显示，30min和120min血糖水平与高血压组相比，对照组和坎地沙坦给药组明显降低（P〈0．05）。血清脂联素的水平与高血压组相比，对照组和坎地沙坦大鼠明显较高（P〈0．05）。结论：血管紧张素Ⅱ受体拮抗剂坎地沙坦可以升高高血压血清脂联素水平，改善IR，降低30、120min餐后血糖水平。

Effect of candesartan on HOMA-IR and serum adiponectin of sponta- neously hypertensive rats

AIM： To investigate the effect of candesartan, an angiotensin II receptor antagonist, on HOMA-IR and serum adiponectin of spontaneously hypertensive rats （ SHRs ）. METHODS： SHRs were divided into two groups： Hypertension group （SHR, n= 30）, Candesartan group （ Candesartan, 1 mg. kg 1 . d-l, n = 30, gavaging for 12 weeks）. WKY rats were the control group （WKY, n = 30）. The other two groups were given a placebo. Fasting blood glucose and ser um insulin were measured by biochemistry methods, insulin resistance index （HOMA-IR） was calculated,OGTT was tested by biochemis try methods. Changes of serum adiponectin were measured by ELISA. RESULTS：No difference in the fasting blood glucose of the three groups （P 〉0.05） was observed. Serum insulin level andHOMA-IR of SHRs were higher than those of WKY and drug groups （P〉0.05）. Candesartan could not reduce those of SHRs. Serum adipone ctin level of SHRs was lower than that of WKY, and candesartan could obviously increase that of SHRs （P〉0.05）. The result of OGTT showed that blood glucose level at 30 min or 120 min in hypertension group compared with control group and candesartan group were higher. CONCLU- SION： Candesartan could ameliorate the upregu laiton of serum adiponectin in SHR, improve in-sulin resistance and reduce blood glucose level of SHR at 30 min and 120 min.