Nucleotide sequence of genome segment 5 from Bombyx mori cypovirus 1 |
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| Authors: | K Hagiwara J Kobayashi M Tomita T Yoshimura |
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| Institution: | (1) Venture Laboratory, Kyoto Institute of Technology, Kyoto, Japan, JP;(2) Department of Chemistry for Materials, Faculty of Engineering, Mie University, Mie, Japan, JP |
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| Abstract: | Summary. The complete nucleotide sequences of the double-stranded RNA genome segments 5 (S5) from Bombyx mori cypovirus 1 (BmCPV-1) strains I and H were determined. The segments consisted of 2,852 nucleotides encoding putative proteins
of 881 amino acids with molecular masses of approximately 101 kDa (p101). A homology search showed that p101 has high similarity
(93%) to foot-and-mouth disease virus (FMDV) 2A protease (2Apro) at amino acid position 219 to 235. These findings suggest the possibility that p101 encoded by BmCPV-1 S5 might be cleaved
into two non-structural proteins by post-translational autocleavage involving a 2Apro-like protease.
Received February 21, 2000 Accepted June 23, 2000 |
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