静脉留置针注射不同性质药物对血管损伤的实验观察

目的:探讨静脉留置针在输入不同性质药物时留置时间与血管损伤程度的相关性?方法:选取大耳新西兰白兔60只随机分为A?B?C 3组,每组20只,取其双耳外缘静脉作为实验血管,留置针穿刺置管?A组注射多柔比星,B组注射20%甘露醇,C组注射生理盐水,1次/天,用药后肝素盐水封管?各组于用药第2?4?6?8?10天分别取4只腹腔麻醉切取活体标本做切片,观察血管及周围组织的病理变化?结果:3组留置相同时间炎症反应比较:第2天 P > 0.05;第4?6天P < 0.05;第8?10天P > 0.05?血栓形成比较:第2?4天P > 0.05;第6?8?10天P < 0.05?同一组不同部位的炎症反应?血栓形成情况比较:P < 0.05?结论:应用静脉留置针注射不同药物时留置时间不应相同,强刺激性药物留置时间一般以2天为宜,最多不超过3天,弱刺激性药物时可适当延长留置时间,但以不超过7天为宜?

An experimental study on vascular injury induced by injection of different types of drugs with intravenous catheter system

Objective:To study the relationship between the indwelling time of intravenous catheter system injection of different types of drugs and degree of vascular injury. Methods:Totally 60 New Zealand rabbits were selected as study samples and evenly divided into three groups randomly. The veins at the edges of the two ears were taken out as the tested blood vessels for the infusion with intravenous catheter system. The three groups were injected respectively with doxorubicin,20% mannitol and physiological saline once daily,and then blocked with heparin salt water. After intraperitoneal anesthesia,pathological sections were prepared by taking live samples from the ear vein where intravenous catheter system puncturing on the 2 nd,4 th,6 th,8 th and 7 th day of transfusion,and changes of vascular and peri-vascular tissues were observed under microscope. Results:In the same indwelling time,the inflammatory response of the three groups was compared:there were no differences at the 2nd,8th and 10th day(P > 0.05),but significant differences were observed on the 4 th,6 th day(P < 0.05). Comparison of thrombosis showed that there were no differences at the 2 nd,and,4 th day(P > 0.05)but with markable difference observed at the 6 th,8 th and,10 th day(P < 0.05). The comparison of inflammatory response and thrombosis situation in different parts in the same group showed obviously difference(P < 0.05). Conclusion:The indwelling time of Intravenous Catheter System should be set according to the type of drugs. Two-day of indwelling time is suitable for strong irritant substances,which should not be more than 72 h. The indwelling time of the weak irritant drugs by intravenous catheter system injection may be appropriate to extend with limitation of 7 days.