舒血宁注射液联合瑞舒伐他汀治疗不稳定型心绞痛的临床观察

目的探讨舒血宁注射液联合瑞舒伐他汀治疗不稳定型心绞痛的临床疗效和安全性。方法不稳定型心绞痛患者122例，随机分成2组：对照组60例，给予硝酸酯类、β受体阻滞剂等常规治疗及瑞舒伐他汀20mg，1次·d^-1，每晚睡前口服；治疗组62例，在此基础上加用舒血宁注射液20mL，静脉滴注，qd，均4周为一疗程。观察治疗前后心绞痛控制情况、硝酸甘油含服量、心电图变化、血液流变学指标、血脂水平及c反应蛋白等的变化。结果疗程结束后，对照组和治疗组心绞痛症状控制总有效率分别70．0％和91.3％，2组比较差异有统计学意义（P〈0．01）；心电图总有效率分别为55．0％和71．0％，2组比较差异有统计学意义（P〈0．01）。治疗组血液流变学指标、C反应蛋白及血脂水平的改善均优于对照组，2组比较差异有统计学意义（P〈0．05或P〈0．01）。结论舒血宁注射液联合瑞舒伐他汀治疗不稳定型心绞痛，临床效果好，不良反应少。

Clinical Observation of Shuxuening Injection Combined with Rosuvastatin on Unstable Angina

OBJECTIVE To investigate the therapeutic effect of Shuxuening injection combined with rosuvastatin on unstable angina. METHODS The 122 patients suffering from unstable angina were randomly selected and divided into two groups： the control group（n=60） were given routine treatment such as nitroglycerin, β-receptor blockers, and rosuvastatin taken at night 20 mg per day, while the treatment group（n=62） based on the above plus Shuxuening injection 20 mL intravenous trip, once a day. The two groups were treated for 4 weeks. The indexes of angina, sublingual nitroglycerin, electrocardiogram, blood theology, blood lipds and serum levels of C-reactive protein were observed before and after treatment. RESULTS After treatment, the total effective rates of angina pectoris symptom in control group and treatment group were 70.0% and 91.3%, respectively, there was significant difference between the two groups（P〈0.01）; total effective rate of ECG were 55.0% and 71.0% respectively, there was significant difference between the two groups（P〈0.01）. Blood rheology, C-reactive protein and blood lipid treatment group of level were better than the control group, there were significant difference between the two groups（P〈0.05 or P〈0.01）. CONCLUSION angina pectoris has good clinical effect and less The treatment of Shuxuening injection combined with rosuvastatin on unstable adverse reaction.