| 131I治疗分化型甲状腺癌患者唾液腺损伤的影响 |
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| 引用本文： | 李少华,王自正,王〓峰,姚薇萱,邵国强,蒋〓娥,张乐乐,孟庆乐.131I治疗分化型甲状腺癌患者唾液腺损伤的影响[J].南京医科大学学报,2010(7):998-1001. |
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| 作者姓名： | 李少华 王自正 王〓峰 姚薇萱 邵国强 蒋〓娥 张乐乐 孟庆乐 |
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| 作者单位： | 南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006;南京医科大学附属南京第一医院核医学科,江苏 南京〓210006 |
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| 摘 要： | 目的:了解分化型甲状腺癌(differentiated thyroid carcinoma,DTC)的患者经大剂量131I治疗后,慢性唾液腺损伤的发病情况?方法:143例分化型甲状腺癌的患者经手术切除后行大剂量的131I治疗,在131I治疗前和治疗后的6~39个月随访中分别行唾液腺功能显像?结果:143例DTC患者中有31例(21.7%)出现慢性唾液腺损伤,131I治疗2次以上(累积剂量7.4~37.0 GBq)发生慢性唾液腺损伤的发病率明显高于131I治疗1次者(累积剂量<3.7 GBq)(P < 0.005)?结论:反复的?大剂量131I治疗引起的慢性唾液腺损伤更多见?
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| 关 键 词： | 唾液腺 放射性碘治疗 甲状腺癌 |
| 收稿时间： | 1/5/2010 12:00:00 AM |
Damage of salivary gland function induced by 131I treatment in patients with differentiated thyroid carcinoma |
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| LI Shao-hu,WANG Zi-zheng,WANG Feng,YAO Wei-xuan,SHAO Guo-qiang,JIANG E,ZHANG Le-le and MENG Qing-le.Damage of salivary gland function induced by 131I treatment in patients with differentiated thyroid carcinoma[J].Acta Universitatis Medicinalis Nanjing,2010(7):998-1001. |
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| Authors: | LI Shao-hu WANG Zi-zheng WANG Feng YAO Wei-xuan SHAO Guo-qiang JIANG E ZHANG Le-le and MENG Qing-le |
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| Institution: | Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China;Department of Nuclear Medicine Center,Nanjing First Hospital Affiliated to NJMU,Nanjing 210006,China |
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| Abstract: | Objective:To investigate the chronic function damage of the salivary gland by high dose of 131I in the treatment of differentiated thyroid carcinoma(DTC). Methods:Salivary gland scintigraphy,for function evaluation,were made before and 6~39 months after high dose of 131I treatment on 143 patients with DTC after thyroid ablation. Results:21.7%(31/143)patients with DTC suffered from chronic salivary gland damage after 131I treatment. And the incidence of chromic damage was more predominant in patients received repeated 131I therapy(aggregated dose ranging from 7.4~37.0 GBq)than those treated with once 131I therapy(dose less than 3.7 GBq).(P < 0.005). Conclusion:Repeating and large dose of 131I treatment is more common in the causes of chronic salivary gland damage. |
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| Keywords: | salivary glands radioiodine thyroid cancer |
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