中国苏皖地区汉族人群KLOTHO基因启动子G-395A多态性与ACS相关性分析

目的:探讨KLOTHO基因启动子区G-395A多态性与中国苏皖地区汉族人群急性冠脉综合征(acute coronary syndrome,ACS)的关系?方法:采用聚合酶链反应和基因芯片方法对326例ACS(ACS组)分为亚组急性心肌梗死(acute myocardial infarction,AMI)组和不稳定性心绞痛(unstable angina pectoris,UAP)组]和219例经检查排除冠心病的对照组进行KLOTHO基因G-395A多态性分析?结果:与对照组相比,ACS组?AMI组和UAP组(包括不同年龄和不同性别的亚组)的GG?GA?AA基因型和A等位基因频率均无明显差异(P > 0.05)?结论:KLOTHO基因G-395A多态性与中国苏皖地区汉族人群ACS的发病无显著相关性?

KLOTHO gene promoter G-395A polymorphisms of acute coronary syndrome in the Chinese Han population of Suwan region

Objective:To investigate the possible association between the KLOTHO gene G-395A polymorphisms in promoter and acute coronary syndrome (ACS) in the Chinese Han population of Suwan region. Methods:This study was conducted with a case-control design including ACS group which is consisted of 326 patients with acute myocardial infarction (AMI) and unstable angina pectoris (UAP) and control group which is consisted of 219 subjects without coronary artery disease by coherence checks. The KLOTHO gene G-395A polymorphisms was determined by polymerase chain reaction(PCR) and gene microarray. Results:Compared with those in the control group,the frequencies of GG,GA,AA genotype and the A allele of the G-395A was not significantly different among ACS,AMI and UAP group,which were subgrouped according to gender and age (all P > 0.05). Conclusion:The G-395A polymorphisms in KLOTHO gene may not be the risk for ACS in the Chinese Han population of Suwan region.