| 脂源性分泌因子leptin?resistin?adiponectin?visfatin mRNA在子痫前期患者胎盘组织中表达及意义 |
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| 引用本文： | 王〓欣,王小青,刘晓梅,花向东.脂源性分泌因子leptin?resistin?adiponectin?visfatin mRNA在子痫前期患者胎盘组织中表达及意义[J].南京医科大学学报,2009,29(12):1724-1726. |
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| 作者姓名： | 王〓欣 王小青 刘晓梅 花向东 |
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| 作者单位： | 南京医科大学附属南京妇幼保健院产科,江苏 南京〓210004 |
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| 摘 要： | 目的:探讨子痫前期患者胎盘组织中脂源性分泌因子瘦素(leptin)?抵抗素(resistin)?脂联素(adiponectin)?内脂素(visfatin) mRNA表达水平及其意义?方法:采用RT-PCR方法测定36例正常足月妊娠妇女(A组)?24例轻度子痫前期患者(B组)和17例重度子痫前期患者(C组)胎盘组织中脂源性分泌因子leptin?resistin?adiponectin?visfatin mRNA表达水平?结果:①C组leptin?resistin mRNA表达水平分别为1.361±0.261?1.515±0.177,显著高于B组的0.898±0.201?1.055±0.113和A组的0.559±0.175?0.508±0.119(P < 0.05);②C组adiponectin mRNA表达水平为0.222±0.115,显著低于B组的0.776±0.176和A组的1.422±0.193(P < 0.05);③C组visfatin基因mRNA表达水平为0.253±0.119,显著低于B组的1.298±0.193和A组的1.308±0.208(P < 0.05),B组与A组比较无显著差异(P > 0.05)?结论:脂源性分泌因子leptin?resistin?adiponectin?visfatin在子痫前期的发病中有重要作用,可能参与了胰岛素抵抗的病理生理过程?
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| 关 键 词： | leptin resistin adiponectin visfatin 子痫前期 胎盘 |
| 收稿时间： | 2009/7/11 0:00:00 |
Leptin,resistin,adiponectin,and visfatin mRNA levels in placental tissues of patients with preeclampsia |
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| WANG Xin,WANG Xiao-qing,LIU Xiao-mei and HUA Xiang-dong.Leptin,resistin,adiponectin,and visfatin mRNA levels in placental tissues of patients with preeclampsia[J].Acta Universitatis Medicinalis Nanjing,2009,29(12):1724-1726. |
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| Authors: | WANG Xin WANG Xiao-qing LIU Xiao-mei and HUA Xiang-dong |
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| Institution: | Department of Gynecotogy,Nanjing Maternity and Child Care Hospital Affilited to NJMU,Nanjing 210004,China |
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| Abstract: | |
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| Keywords: | leptin resistin adiponectin visfatin preeclampsia placenta |
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