首发抑郁症患者治疗前后高兴体验的fMRI改变

目的:应用功能磁共振(fMRI)技术,探讨首发抑郁症患者药物治疗前后体验高兴表情的脑功能区变化特点?方法:采用3.0 T磁共振,对13例首发抑郁症患者(分别于抗抑郁药物治疗前及治疗8周后)和14例性别?年龄相匹配的正常志愿者进行fMRI检查?运用SPM2分析软件,比较体验高兴表情(与中性表情对照)的脑功能区变化?结果:高兴体验时,治疗前患者组左侧额上?中回背外侧皮层活动性较正常人减低(P < 0.001,uncorrected),经过治疗后恢复(P < 0.001,uncorrected)?结论:高兴体验的fMRI可以作为一项客观评价抗抑郁药物疗效的生物学指标?

Neural responses with happy emotional processing of patients with first-onset major depressive disorder by antidepressant treatment investigated with functional MRI

Objective:To detect changes of neural response on happy facial expressions in first-onset major depressive disorder(MDD)by antidepressant treatment investigated with functional magnetic resonance imaging (fMRI). Methods:Thirteen patients with first onset MDD and 14 normal age-matched volunteers underwent fMRI and patients underwent scanning twice during an 8-week period. Blood oxygenation level dependent(BOLD) was processed using SPM2 to compare the function of whole brain between the two groups exposure to neutral and positive pictures. Results:Decreased activation of left laterial superior frontal cortex exposure to happy pictures was found in patients compared with control group(P < 0.001,uncorrected). Symptomatic improvement after antidepressant was associated with reversion of left laterial superior frontal cortex(P < 0.001,uncorrected). Conclusion:Changes in BOLD of fMRI associated with symptomatic improvement indicate that fMRI may be a useful marker of antidepressant treatment response.