Influence of inhomogeneities in muscle tissue on single-fibre action potentials: a model study |
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| Authors: | W L C Rutten B K van Veen S H Stroeve H B K Boom W Wallinga |
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| Institution: | (1) Institute for Biomedical Technology, Department of Electrical Engineering, Biomedical Engineering Division, University of Twente, PO Box 217, 7500 AE Enschede, The Netherlands;(2) Medtronic Company, Maastricht, The Netherlands;(3) Mechanical Engineering Faculty, Delft University of Technology, Delft, The Netherlands |
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| Abstract: | The influence of changes in electrical conductivity, due to the muscle boundary, layers and compartments of intramuscular
connective tissue and blood vessels, on computed single-muscle fibre action potentials (SFAPs) in rat hindleg muscle is calculated.
The position of the active fibre is varied throughout the muscle. For fibres close to the muscle boundary, peak-to-peak voltages
of SFAPs increase by up to a factor of 3 compared with the unbounded situation. For inner fibres, the presence of nearby connective
tissue compartments causes an increase of up to 40%. A blood vessel in the neighbourhood of the active fibre leads to a decrease
of at most 20%, for recording sites between the active fibre and the blood vessel. For recording sites beyond the blood vessel,
peak-to-peak voltages increase by up to 20%. |
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| Keywords: | Blood vessel Boundary effects Connective tissue Finite-element modelling Single-muscle fibre action potential Volume conduction |
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