布地奈德联合克拉霉素治疗慢性鼻-鼻窦炎疗效观察以及对黏膜组织重塑的影响

目的　探究应用布地奈德联合克拉霉素治疗慢性鼻-鼻窦炎（CRS）疗效观察和对黏膜组织重塑的影响。方法　选取我院收治的90例CRS患者，随机分成布地奈德治疗组、克拉霉素治疗组和布地奈德联合克拉霉素治疗组，比较三组患者治疗前后VAS评分、鼻窦CT评分；比较气道重塑情况和不良反应发生情况等。结果　治疗后，联合治疗组鼻部各症状VAS平均评分、鼻窦CT评分显著优于其他两组（P 均<0.05）；联合治疗组气道损伤程度较轻，基底膜增厚不明显，转化生长因子β1灰度值显著大于其他两组（P <0.05）；患者服药后不良反应发生较少，均经过相关治疗得以转归。结论　采用布地奈德联合克拉霉素能够显著改善CRS患者病况，减轻黏膜组织重塑，值得在临床上广泛推广。

Effect of Budesonide combined with clarithromycin on chronic rhinosinusitisandits mucosa remodeling

OBJECTIVE To explore the application of Budesonide combined with clarithromycin in the treatment of patients with chronic rhinosinusitis(CRS) and observe the effect on mucosa tissue remodeling.METHODS 90 cases of CRS patients were selected in our hospital.They were randomly divided into Budesonide treatment group,clarithromycin treatment group and the two combined treatment group.VAS score,sinus CT Score were compared among the three groups before and after treatment.Airway remodeling and the occurrence of adverse reactions were also compared among the three groups.RESULTS After treatment,VAS score and Sinus CT scoreof the combined treatment groupwere significantly better than that of the other two groups(P＜0.05);Airway damage in combined treatment group was also lighter,basement membrane thickening was not obvious.The gray value of TGF-β1 in the combined treatment group was significantly higher than that of the other two groups(P＜0.05);Drug adverse reaction occurred less and resolved after treatment.CONCLUSION Budesonidc combined with clarithromycin can significantly improve the state of illness in patients with CRS and alleviate mucosal tissue remodeling.It is worthy of recommendation in clinical practice.