Primary Small Cell Neuroendocrine Carcinoma of the Kidney |
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Authors: | K. G. Morgan S. S. Banerjee B. P. Eyden R. J. Barnard |
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Affiliation: | a Department of Pathology, Christie Hospital NHS Trust, Manchester, United Kingdomb Department of Surgery, Christie Hospital NHS Trust, Manchester, United Kingdom |
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Abstract: | The histological, immunohistochemical, and ultrastructural features of a primary small cell neuroendocrine carcinoma of the renal parenchyma are described. Tumor cells were positive for cytokeratin, neuron-specific enolase, and Leu 7, but Grimelius- and chromogranin-negative. They also exhibited positivity with anti-MIC2 antibody. By electron microscopy, tonofibrils, primitive desmosomes, and dense-core granules with a neuroendocrine appearance were present. This is only the 7th recorded example of such a tumor at this site, which showed an aggressive course characterized by widespread bony metastases. |
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Keywords: | cytokeratin immunohistochemistry kidney neuroendocrine granule small cell neuroendocrine carcinoma ultrastructure |
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