聚肌胞对小鼠前列腺癌的抑制作用

目的：观察聚肌胞对小鼠前列腺癌的抑制作用。方法：将16只C₅₇BL6/J纯系荷瘤小鼠按瘤重采用区组随机分组方法分为对照组和聚肌胞组，每组8只，每隔2日分别瘤内注射生理盐水和聚肌胞，第7次后切除瘤灶，称瘤重，计算瘤重抑制率，绘制前列腺癌生长曲线及荷瘤鼠生存曲线。前列腺癌组织HE染色观察形态学变化。结果：对照组和聚肌胞组瘤重分别为（4.14±1.56）和（1.58±0.67）g，两组瘤重比较差异具有显著性（P<0.05）；聚肌胞组瘤重抑制率为67.85%；前列腺癌生长曲线显示，聚肌胞组小鼠前列腺癌生长较慢；聚肌胞组荷瘤小鼠的生存时间较对照组长(P<0.05)；病理显示对照组较聚肌胞组前列腺癌细胞增殖活跃。结论：聚肌胞可以减慢小鼠前列腺癌的生长，延长荷瘤小鼠生存时间。

Inhibitory effects of polyI: C on prostate carcinoma in mice

Objective To evaluate the inhibitory effect of the polyI:C on subcutaneous prostate carcinoma of mice. Methods The mouse prostate carcinoma models were established by inoculating RM-1 cells to subcutaneous tissue of mice. Then the mice were randomly divided into two groups: control group and polyI:C group according to tumor weight(n=8) .After seven times′ treatment, the prostate carcinoma was separated from mice and the tumor and mouse weight were measured and the inhibitory rates of polyI:C was calculated. The tumor growth curves and mice survival curves were drew. HE staining was used to evaluate the morphological changes of prostate carcinoma tissue. Results The tumor weights in control and polyI:C group were (4.14±1.56) and (1.58±0.67)g ,respectively,and there was significant difference between two groups(P<0.05). The tumor inhibitory rate of polyI:C was 67.85%. The tumor growth curves showed that the growth of polyI:C group was slower than that in control and the mouse survival curves showed that there was significant difference of mouse survival time between two groups (P<0.05).HE staining showed that the cell proliferation in control group was more active than that in polyI:C group. Conclusion PolyI:C can strongly inhibit not only the growth but the migration rate and death rate of prostate carcinoma.