Gefitinib-induced pneumonitis in non-small cell lung cancer: radiological and clinical findings in five patients |
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Authors: | Park Hee Sun Lee Hyun Ju Im Jung-Gi Goo Jin Mo Lee Chang-Hyun Park Chang Min Chun Eun Ju |
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Institution: | Department of Radiology, Seoul National University College of Medicine, Seoul 110-744, South Korea. |
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Abstract: | PURPOSE: The objective of this study was to describe the radiological and clinical features of gefitinib-induced pneumonitis in non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Five patients who suffered dyspnea after gefitinib treatment were selected. Chest radiographs and computed tomography (CT) findings, along with clinical course, were evaluated. RESULTS: Patients complained of subacute dyspnea and hypoxia. Three patients improved after discontinuation of gefitinib, while remaining two showed no response. Unilateral or bilateral ground glass opacity was observed on chest radiographs and CT. CONCLUSION: Radiological findings of gefitinib-induced pneumonitis were nonspecific, but radiologists should be aware of this adverse reaction, which can appear during the treatment in NSCLC patients. |
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