Involvement of hyaluronidases in colorectal cancer |
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| Authors: | Helen Bouga Isidoros Tsouros Dimitrios Bounias Dora Kyriakopoulou Michael S Stavropoulos Nikoletta Papageorgakopoulou Dimitrios A Theocharis Demitrios H Vynios |
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| Affiliation: | (1) Laboratory of Biochemistry, Department of Chemistry, University of Patras, Patras, Greece;(2) Department of Surgery, University Hospital, Patras, Greece;(3) Laboratory of Biological Chemistry, Department of Medicine, University of Patras, Patras, Greece |
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| Abstract: | Background Hyaluronidases belong to a class of enzymes that degrade, predominantly, hyaluronan. These enzymes are known to be involved in physiological and pathological processes, such as tumor growth, infiltration and angiogenesis, but their exact role in tumor promotion or suppression is not clear yet. Advanced colorectal cancer is associated with elevated amounts of hyaluronan of varying size. The aim of the present study was therefore to illuminate the importance of hyaluronidases in colon carcinoma progression. |
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