| 卡托普利对胰岛素抵抗-高血压综合征大鼠肾素及血脂的影响 |
| |
| 引用本文： | 李杰,肖柳英,潘竞锵. 卡托普利对胰岛素抵抗-高血压综合征大鼠肾素及血脂的影响[J]. 中国药业, 2008, 17(11): 12-13 |
| |
| 作者姓名： | 李杰 肖柳英 潘竞锵 |
| |
| 作者单位： | 1. 广东省广州市药材公司,广东,广州,510140
2. 广东省广州市中医医院·中医中药研究所,广东,广州,510130 |
| |
| 基金项目： | 广东省中医药管理局科研项目 , 广州市中西医结合项目 |
| |
| 摘 要： | 目的研究卡托普利对胰岛素抵抗-高血压综合征（IRH）大鼠肾素和血脂的影响。方法用喂饲高糖高盐高脂的方法建立IRH病理模型，将大鼠随机分为模型组及卡托普利组，测定血浆胰岛素、空腹血糖、血脂、肾素以及给药前后的血压变化。结果卡托普利7mg／（kg·d）能明显降低IRH大鼠的肾素、血压、甘油三酯和总胆固醇（P〈0．05），能改善IRH的高胰岛素血症，提高低下的胰岛素敏感指数（P〈0．01）。结论卡托普利能有效增强胰岛素的敏感性，降低IRH大鼠肾素的含量，降低高血压。
|
| 关 键 词： | 卡托普利 肾素 血脂 胰岛素抵抗 高血压 大鼠 |
| 文章编号： | 1006-4931(2008)11-0012-02 |
| 修稿时间： | 2007-08-16 |
Experimental Study on Effect of Captopril on Renin and Blood Lipid in Insutin Resistant Hypertensive Rats |
| |
| Li Jie,Xiao Liuying,Pan Jingqiang. Experimental Study on Effect of Captopril on Renin and Blood Lipid in Insutin Resistant Hypertensive Rats[J]. China Pharmaceuticals, 2008, 17(11): 12-13 |
| |
| Authors: | Li Jie Xiao Liuying Pan Jingqiang |
| |
| Affiliation: | Li Jie, Xiao Liuying, Pan Jingqiang (1. Guangzhou Chinese Medicine Corporation, Guangzhou, Guangdong, China 5101403; 2. Guangzhou Institute of Traditional Chinese Medicine and Material, Guangzhou, Guangdong, China 510130) |
| |
| Abstract: | Objective To study the effect of captopril （Cap） on renin and blood lipid in insulin resistant hypertensive （IRH） rats. Methods Feeding high fat, sugar and salt for 8 weeks to set up the model of IRH rats. And the rats were divided into 2 groups. The changes of blood pressure, contents of fasting blood glucose, fasting insulin （FINS）, serum renin and blood lipid were measured. Results Captopril 7 mg/（kg·d） could significantly decrease the blood pressure, contents of renin and blood lipid （P〈0. 05）. Cap could significantly decrease the FINS, improve the hyperinsulinmia and promote the lowered insulin sensitivity index （P〈0. 01） in IRH rats. Conclusion Cap can decrease blood pressure and enhance the insulin sensitivity, decrease the contents of renin and blood lipid in IRH rats. |
| |
| Keywords: | captopril renin blood lipid insulin resistance hypertension rats |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
