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| 益肾方对自发性高血压大鼠肾脏保护作用的研究 | |
| 引用本文： | 徐向东,徐向青,侯秀娟.益肾方对自发性高血压大鼠肾脏保护作用的研究[J].辽宁中医杂志,2004,31(7):615-616. |
| 作者姓名： | 徐向东 徐向青 侯秀娟 |
| 作者单位： | 1. 山东中医药大学附属医院,山东,济南,250011 2. 北京中医药大学博士后工作站,北京,100029 3. 北京中医药大学2002级博士研究生,北京,100029 |
| 摘 要： | 目的 :通过实验研究 ,探讨益肾方的肾保护作用及机理 ,以期为中医药防治高血压肾损害作出有益的探索。方法 :实验选择自发性高血压大鼠 (SHR) ,观察益肾方的降压及肾保护作用。结果 :益肾方能明显降低SHR血压 ,增加大鼠肾组织的血流量 ,降低SHR肾组织中AngⅡ水平 ,下调转化生长因子基因表达。病理观察显示益肾方能减轻肾小球毛细血管基底膜增厚及系膜细胞增生 ,延缓肾小球硬化。结论 :补肾活血是治疗高血压肾损害的重要治法。益肾方有确切的降压及肾保护作用 |
| 关 键 词： | 自发性高血压大鼠 实验研究 补肾活血 肾保护 中医药疗法 |
| 文章编号： | 1000-1719(2004)07-0615-02 |
| 修稿时间： | 2004年3月8日 |
The study of Yishenfang's protective effect on kidney of SHR |
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| XU Xiang dong\,XU Xiang qing\,HOU Xiu juan\.The study of Yishenfang''''s protective effect on kidney of SHR[J].Liaoning Journal of Traditional Chinese Medicine,2004,31(7):615-616. | |
| Authors: | XU Xiang dong\ XU Xiang qing\ HOU Xiu juan\ |
| Institution: | XU Xiang dong\+1,XU Xiang qing\+2,HOU Xiu juan\+3 |
| Abstract: | Objective :This research try to evaluate Yishenfang′s protective effect on kidney through experiental study,so as to make a beneficial attempt in this field in traditional Chinese medicine. Methods :Yishenfang′s protective effect on kidney was observed through SHR models in experimental study. Results :Experimental study showed that Yishenfang can control blood-pressure of SHR models,improve quantum of blood in kidney,decrease the level of Ang Ⅱ in kidney of SHR and inhibit the expression of TGF-β 1 mRNA in kidney.Pathological research showed that Yishenfang can reduce the damage and postpone sclerosis in kidney of SHR. Conclusion :Strengthening kidney and promoting blood circulation is a important therapeutic rule in treating senile hypertension.Yishenfang has good antihypertensive effect and protective effect on kidney. |
| Keywords: | SHR experimental study strengthening kidney and promoting blood circulation protective effect on kidney TCM therapy |
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