Lactoferrin, C-reactive Protein, α-1-Antitrypsin and Immunoglobulin GA in Cerebrospinal Fluid in Meningitis |
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Authors: | T J GUTTEBERG T FLÆGSTAD T JØRGENSEN |
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Institution: | Departments of Paediatrics and Immunology, University Hospital, Tromsø, Norway |
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Abstract: | ABSTRACT. Cerebrospinal fluid measurements of lactoferrin and α-1-antitrypsin showed significant elevation in bacterial meningitis in children. 8 of 10 lactoferrin values and 6 of 11 α-1-antitrypsin values were above the upper range of controls. Both proteins correlated well with the total number of leukocytes in the cerebrospinal fluid. C-reactive protein, measured by either agglutination or radial immunodiffusion in the cerebrospinal fluid, failed to demonstrate any asefulness in diagnosing bacterial meningitis. Neither elevated serum C-reactive protein in cases of bacterial meningitis, nor sepsis, gave detectable concentrations of C-reactive protein in the cerebrospinal fluid. |
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Keywords: | Children bacterial meningitis cerebrospinal fluid α-1-antitrypsin C-reactive protein lactoferrin |
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