脊髓灰质炎疫苗免疫的研究 Ⅱ.不同剂型的脊髓灰质炎疫苗免疫应答的比较

在江苏武进县农村对2~6月龄未服过脊髓灰质炎疫苗易感儿中,比较液体Ⅰ型,糖丸Ⅰ型和三价糖丸疫苗免疫应答。3种疫苗3次免疫后,抗体阳转率均达到95~100%,无统计学显著性差异,抗体几何平均滴度以液体Ⅰ型最高,液体Ⅰ型与糖丸Ⅰ型、Ⅰ型糖丸与三价糖丸无显著性差异,但三价糖丸与液体Ⅰ型相比有显著性差异。鉴于2~4月龄婴幼儿服用糖丸十分不便,且不易保证服苗效果,建议生产厂家克服困难创造条件尽快将脊灰糖丸剂型改为液体剂型。

A study on immunization of polio vaccine. II. Comparison of responses obtained by different forms of polio vaccine]

A comparison study on the responses to the immunization of three different forms of polio vaccine, eg. Liquid I, Oral dragee candy I and Trivalent Oral dragee candy, on the susceptible children of 2-6 month of age was conducted in wujin County, Jiangsu Province The study showed no statistical difference between the responses to the three forms of the vaccine reaching 95-100%. For antibody GMT, Liquid I was the highest, with little difference between Liquid I and Oral dragee candy I and Trivalent Oral dragee candy vaccine in statistics. But, there was a significant statistical difference between Trivalent Oral dragee candy and Liquid I. Considering that it is not easy to inoculate the children of 2-4 months of age with oral dragee candy vaccine, it is suggested all the producers try their best to convert the present oral dragee candy form into Liquid.