我国流脑周期性流行特征的研究

本文报道了,通过应用多位点酶电泳分型后的聚类分析与染色体DNA酶切谱分型以及i类外膜蛋白的(OMP)分亚型等技术,对本国17省市于本世纪60年代至80年代从流脑病人与带菌者中所分离的200株A群脑膜炎奈瑟氏菌(Nm)进行了菌型检定并结合本国近40年来流脑的发病率资料进行了综合分析。研究结果证明了本国流脑确实具有周期性流行的特征,不同的周期流行是由A群Nm不同优势菌型周期变换引起的,每次周期流行基本上是从本国北方向南方扩散。不过,此病在我国周期性流行的模式不大固定。该项研究为今后应用分子生物学方法揭示流脑的流行机制奠定了初步基础。

Study on Periodically Prevalent Feature for Epidemic cerebrospinal Meningitis in China

A study on periodically prevalent feature for epidemic cerebrospinal meningitis (ECM) in China was carried out by means of cluster analysis of multilocus enzyme electrophoresis, as well as chromosomal DNA fingerprinting and subserotyping of outer membrane protein class 1 of Neisseria meningitidis group A. Two hundred strains tested were isolated from the patients for ECM and carriers during the 1960s to 1980s in 17 provinces and municipalities. Overall analysis on the bacterial types of the strains above mentioned and data of morbidity of this disease for recent 40 years was undertaken. The research results indicated that ECM really possessed the feature of cyclic prevalence in China, the cyclic epidemics were caused by the different predominant types of Neisseria meningitidis group A and the strains of predominant types could be periodically spread. Every epidemic was basically spread from the north to the south of China. However, the patterns of cyclic epidemic of this disease were not uniform in the country. The above study has established the preliminary base to reveal the prevalent mechanism for ECM by use of molecular biological methods in China.