单采浆还输血球献血员中丙型肝炎病毒感染的流行病学和血清学研究

本文报告单采浆献血员中丙型肝炎病毒(HCV)感染的流行病学和血清学研究结果。通过对5个自然村3 496人流行病学调查表明,单采浆献血员肝炎现患率和单项ALT异常率分别为17.10%和23.23%,二者均显著高于全血献血员和非献血员成人。经排除法证明,上述肝炎患者绝大多数为肠道外传播的非甲非乙型肝炎。后将部分单采浆献血员肝炎病例和单项ALT异常者的血清标本,送美国疾病控制中心检测,抗-HCV阳性率分别为97.06%和100%。证实为HCV感染。流行病学调查表明,单采浆献血员HC流行是由单采浆还输血球过程中交叉感染引起的。

Epidemiological and Serological Study on Hepatitis C Virus Infection in Plasmapheresis Donors

An epidemic of hepatitis C virus infection in plasmapheresis donors which occurred in 1985 in Gu-An county, Hebei province, was studied. A total of 3,496 persons in five villages were investigated. The prevalence rates of viral hepatitis and elevated ALT levels alone in plasmapheresis donors were 17.10% and 23.23%, respectively, which were significantly higher than these of whole blood donors and controls. 59 sera collected from plasmapheresis donors with viral hepatitis and elevated ALT levels alone were sent to the Centers for Disease Control, USA, for detection of anti-HCV with Chiron C100 (EIA). The positivity rates of anti-HCV were 97.06% and 100%, respectively, indicating that the epidemic was caused by hepatitis C virus.