原代地鼠肾细胞狂犬疫苗人体再免和狂犬病接触前预防可行性的研究

本研究证实原代地鼠肾细胞狂犬疫苗人体再免后有良好的抗体回忆应答。人体以两支疫苗做基础免疫,其后亦无需定期加强,七年内一支再免后的抗体回忆应答没有显著性差异(P>0.05)。再免后7天即有85.71%再免者产生抗体,7天时的抗体水平与常规五针法在45天时的高峰水平接近。7、14、30天的抗体阳转率再免法较常规法极显著地增高(P<0.005),再免后抗体持续时间明显延长。以上结果提示在我国实行接触前预防狂犬病有明显的优越性和可行性。

Study of Revaccination with PHKC-RV in Human Beings and Its Possibility of Pre-exposure Prvention of Rabies

This paper reported that revaccination of antirabies PHKC-RV led to strong increase of antibody after two-dose immunization, vaccinees were reimmunized once with PHKC-vaccine within 7 years (ranging from 6 months to 7 years). Then 7 days later seroconversion was found in 85.71% revaccinees. The antibody level in 7th days of revaccinees was similar to those in 45th days of primary routine five-dose vaccination. In comparison of 7th, 14th, 30th-day level, reimmunization was significantly more effective than routine method (P less than 0.005). In addition, the antibody produced by reimmunization lasted much longer. So it implied that pre-exposure immunization for rabies control has its advantage and feasibility.