胃癌患者血清可溶性P-选择素和细胞间黏附分子-1的表达

目的:探讨胃癌患者手术前后血清可溶性P-选择素(sP-selectin)、细胞间黏附分子-1(sICAM-1)的表达及临床意义.方法:采用ELISA法检测40例胃癌患者术前、术后15 d、术后30 d及20例对照的血清sP-selectin、sICAM-1水平.结果:胃癌患者血清sP-selectin、sICAM-1水平均高于对照组(P＜0.01);术后15 d下降,仍高于对照组水平(P＜0.05);术后30 d降至对照组水平(P＞0.05).血清sP-selectin、sICAM-1水平与胃癌的淋巴结转移和临床分期相关(P＜0.05),与患者年龄、性别、肿瘤大小及组织学分级无明显相关(P＞0.05).结论:sP-selectin、sICAM-1参与了胃癌的发生发展,可成为判断预后的一个重要指标.

Expression of serum soluble P-selectin and intercellar adhesion molecule-1 in patients with gastric carcinoma

Aim: To investigate the expression and clinical significance of soluble P-selectin (sP-selectin) and intercellar adhesion molecule-1(sICAM-1) in patients with gastric carcinoma. Methods:The serum sP-selectin and sICAM-1 levels of 40 patients with gastric carcinoma and 20 normal control were tested by ELISA technique before operation and at 15 days, and 30 days after operation.Results: The serum sP-selectin and sICAM-1 levels in patients with gastric carcinoma were significantly higher than those in normal control (P<0.01), and decreased at 15 days after operation, but still higher than those in control (P<0.05), and the levels decreased to those of control at 30 days after operation (P> 0.05). The serum sP-selectin and sICAM-1 levels of patients with gastric carcinoma were correlated with the metastases of lymph node and the clinical stages (P<0.05), but not to sex, age, tumor size or histological grades (P>0.05).Conclusion: sP-selectin and sICAM-1 are involved in the progression of gastric carcinoma and may be used as a useful index for evaluating prognosis of gastric carcinoma.