奥曲肽治疗急性胰腺炎

目的：观察奥曲肽治疗急性胰腺炎的效果。方法：４３例急性胰腺炎病人分成２组，皆用常规疗法，治疗组２１例加用奥曲肽１００μｇ，ｓｃ，随后６００μｇ溶于５％葡萄糖液１０００ｍＬ中静脉滴注２４ｈ，２组病例都观察腹痛时间、哌替啶总用量、检测胰腺水肿变化及记录血液主要生化指标。结果：治疗组无死亡及外科手术病例，哌替啶总用量仅７０±２７ｍｇ，腹痛缓解及胰腺水肿改善所需时间分别是１．２±０．５ｄ和８．５±２．０ｄ，血淀粉酶恢复正常时间明显优于对照组。用药过程未发现明显不良反应。结论：在常规疗法基础上加奥曲肽对治疗胰腺炎明显有效。

Octreotide in treatment of acute pancreatitis

AIM: To observe the effect of octreotide(Oct) in treatment of acute pancreatitis. METHODS: Forty-three patients with acute pancreatitis were randomly divided into 2 groups: 21 patients were conventional treatment with (Oct group) or without (Control group) supplement of octreotide 100 μg sc and then followed 600 μg in 5% glucose 1000 mL iv infusion for 27±7 h. RESULTS: There were no death and surgical treatment and serum glucose returned to normal in the treatment group. In addition, the consumption of pethidine, time of abdominal pain lysis and time of pancreatic edema improvement were 70±27 mg, 1.2±0.5 d and 8.5±2.0 d, respectively. No obvious adverse reaction were found. CONCLUSION: Supplement of octreotide during conventional therapy is good for treatment of acute pancreatitis.