克山病病区粮对大鼠~(65)Zn代谢的实验观察

本文以克山病病区粮与非病区粮饲养大鼠8周,进行~(65)Zn示踪实验,观察24及72小时血液、心脏、肝、肾及褐脂对~(65)Zn(ZnCl_2)的吸收情况。结果表明,病区组大鼠在两次观察时间,各种组织脏器~(65)Zn的吸收量均高于非病区组,其中肝、肾及褐脂的差异显著。提示病区与非病区粮之间存在差异,即病区粮能使大鼠体内出现锌不足或缺乏。其原因在克山病发生中值得进一步探讨。并对锌与其他元素之间的相互关系进行了讨论。

EXPERIMENTAL OBSERVATION OF 65Zn METABOLISM ON RATS FED ON CROPS FROM ENDEMIC AND NON- ENDEMIC DISTRICTS OF KESHAN DISEASE

Albino rats fed on crops from endemic and non-endemic districts of Ke-shan desease, were used in this experiment, which was studied by 85Zn tracer metabolic method after 8 weeks feeding. Uptake of 85Zn (ZnCl2) by blood, heart, liver, kidneys and brown adipose tissue were determined at 24 and 72 hours after injection of this tracer respectively, and its distribution was thoroughly examined. The results revealed that the uptake of 8aZn was higher in the groups fed on crops from endemic districts, particularly significant in liver, kidneys and brown adipose tissue. This may reflect the lacking or deficiency of zinc in the bodies.The regular differences of 85Zn between two groups were certainly related to the crops produced from endemic or aon-endemic districts. In other words, there should be some differences between crops from endemic and non-endemic areas. Thus more attention should be paid to the factors in endemic crops, which induced lacking or deficiency of zinc in the experimental animal and to its relationship with etiology of Keshan disease.