乳晕下注射示踪剂行前哨淋巴结活检的可行性

目的探讨乳晕下联合注射核素和美蓝行前哨淋巴结活检的可行性。方法选择2004年10月至2007年2月早期乳腺癌患者195例，将患者抽签随机分为两组：一组将示踪剂注射在肿瘤周围（肿瘤周围组）；另一组将示踪剂注射在乳晕下（乳晕下组）。对所有患者均先行前哨淋巴结活检，再行腋窝淋巴结清扫。将所有的前哨淋巴结和非前哨淋巴结均进行常规切片和HE染色检查，对常规病理检查阴性的前哨淋巴结行多层切片和免疫组化检查。结果全组195例，肿瘤周围组98例，乳晕下组97例。肿瘤周围组与乳晕下组前哨淋巴结活检成功率分别为92．9％和97．9％（P=0．17）。经常规病理检查或多层切片加免疫组化检查后，肿瘤周围组有25例SLN阳性，乳晕下组29例SLN阳性。经腋窝淋巴结清扫后，肿瘤周围组有2例SLN为假阴性，假阴性率为7．4％（2／27），乳晕下组有3例假阴性，假阴性率为9．4％（3／32），两组间差异无统计学意义。肿瘤周围组和乳晕下组对腋窝淋巴结预测的准确度分别为97．8％和96．8％，灵敏度分别为92．6％和90．6％，差异均无统计学意义。结论乳晕下注射两种示踪剂行前哨淋巴结活检与肿瘤周围注射相比具有同样预测腋窝淋巴结状况的准确性，同时能避免肿瘤周围注射存在的缺点，是较佳的注射途径。

Feasibility of subareolar injection technique for breast cancer sentinel lymph node biopsy

Objective To compare the results of SLNB by peritumoral and subareolar injection routes and to explore the feasibility of subareolar injection route for breast cancer SLNB. Methods From Oct. 2004 to Feb. 2007, 195 patients with early stage breast cancer were divived randomly into two groups. In one group (the PT group), peritumoral injection of 99mTc sulfur colloid and methylene blue was performed; in the other group(the SA group), subareolar injection of the same tracers was performed. In all patients, com...