| 药用载体星状聚乳酸-羟基乙酸共聚物的合成与表征 |
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| 引用本文： | 肖玉婷,冷迪,李翔,邱立朋,潘卫三,王东凯.药用载体星状聚乳酸-羟基乙酸共聚物的合成与表征[J].沈阳药科大学学报,2010,27(1):11-14. |
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| 作者姓名： | 肖玉婷 冷迪 李翔 邱立朋 潘卫三 王东凯 |
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| 作者单位： | 沈阳药科大学药学院; |
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| 摘 要： | 目的降低水溶性药物微球制剂突释现象。方法以辛酸亚锡为催化剂,采用熔融缩聚法合成星状聚乳酸-羟基乙酸共聚物(star-poly(lactic acid-glycollic acid)copolymer,star-PLGA);采用IR、1H-NMR、GPC、DSC及葡萄糖鉴别反应确证共聚物结构,考察理化性质;以天麻素为模型药物,考察star-PLGA微球和聚乳酸-羟基乙酸共聚物(poly(lactic acid-glycollic acid)copolymer,PLGA)微球的释放行为。结果红外光谱和核磁共振分析结果与文献报道一致;凝胶渗透色谱测定重均相对分子质量为15 178;差示扫描量热分析结果表明star-PLGA为非结晶态;葡萄糖鉴别反应表明star-PLGA中有共价键结合的葡萄糖。Star-PLGA微球能很好地控制突释现象,释放行为平稳,其释放曲线符合Higuchi方程。结论成功合成了star-PLGA(物质的量比50∶50),作为微球制剂的载体star-PLGA能降低水溶性药物的突释现象。
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| 关 键 词： | 星状聚乳酸-羟基乙酸共聚物 红外光谱法 核磁共振氢谱法 凝胶渗透色谱法 差示扫描量热分析法 药用载体 |
| 收稿时间： | 2009-4-20 |
| 修稿时间： | 2009-6-20 |
Synthesis and characterization of star-poly(lactic acid-glycollic acid)copolymer as pharmaceutical materials |
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| XIAO Yu-ting,LENG Di,LI Xiang,QIU Li-peng,PAN Wei-san,WANG Dong-kai.Synthesis and characterization of star-poly(lactic acid-glycollic acid)copolymer as pharmaceutical materials[J].Journal of Shenyang Pharmaceutical University,2010,27(1):11-14. |
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| Authors: | XIAO Yu-ting LENG Di LI Xiang QIU Li-peng PAN Wei-san WANG Dong-kai |
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| Institution: | XIAO Yu-ting,LENG Di,LI Xiang,QIU Li-peng,PAN Wei-san,WANG Dong-kai (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Objective To synthesize and characterize star-poly(lactic acid-glycollic acid)copolymer(star-PLGA)for the pharmaceutical materials of microspheres,in order to reduce the water-soluble drug microspheres burst phenomenon.Methods With stannous octoate as catalyst,melt-polycondensation was used to synthesize star-poly(lactic acid-glycollic acid)copolymer(star-PLGA);infrared spectroscopy(IR),nuclear magnetic resonance spectroscopy(1H-NMR),gel permeation chromatography(GPC),differential scanning calorimetry(DSC)a... |
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| Keywords: | star-poly(lactic acid-glycollic acid)copolymer(star-PLGA) infrared spectroscopy nuclear magnetic resonance spectroscopy gel permeation chromatography differential scanning calorimetry pharmaceutical material |
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