|
|||||
|
|
| 口气清新泡腾片的成型工艺的研究 | |
| 引用本文： | 李志华,龙书可,高崇佳,刘辉,刘炜,张伟娜,邹龙.口气清新泡腾片的成型工艺的研究[J].中南药学,2010,8(4):244-246. |
| 作者姓名： | 李志华 龙书可 高崇佳 刘辉 刘炜 张伟娜 邹龙 |
| 作者单位： | 1. 冷水江市中医院,湖南,冷水江,417500;湖南中医药大学药学院,长沙,410208 2. 湖南中医药大学药学院,长沙,410208 3. 辽宁中医药大学药学院,辽宁,大连,116600 |
| 基金项目： | 湖南省大学生研究性学习和创新性实验计划项目 |
| 摘 要： | 目的研究口气清新泡腾片的成型工艺。方法以崩解时限、发泡量、pH值口感等为评价指标，采用单因素实验优选成型工艺。结果确定最佳工艺条件为：金银花、山楂用水提取2次，合并滤液，浓缩成稠膏，加入茶多酚和乳糖－甘露醇（2：1）干燥后磨粉；选用枸橼酸－酒石酸（2：1）和碳酸氢钠作为泡腾剂，采用外加法添加碳酸氢钠，两步法加入崩解剂CMS-Na，所得泡腾片口感好，硬度适中，吸湿性良好，片重差异小，崩解时限符合规定。结论该制备工艺稳定，可行。 |
| 关 键 词： | 口气清新泡腾片 单因素实验 成型工艺 |
Preparation technology of Fresh breath effervescent tablets |
|
| LI Zhi-hua,LONG Shu-ke,GAO Chong-jia,LIU Hui,LIU Wei,ZHANG Wei-na,ZOU Long.Preparation technology of Fresh breath effervescent tablets[J].Central South Pharmacy,2010,8(4):244-246. | |
| Authors: | LI Zhi-hua LONG Shu-ke GAO Chong-jia LIU Hui LIU Wei ZHANG Wei-na ZOU Long |
| Institution: | LI Zhi-hua1,2,LONG Shu-ke2,GAO Chong-jia3,LIU Hui2,LIU Wei3,ZHANG Wei-na2,ZOU Long2(1.Lengshuijiang Hospital of Traditional Chinese Medicine,Lengshuijiang Hunan 417500,2.Department of Pharmachology,Hunan University of Traditional Chinese Medicine,Changsha 410208,Department of Pharmachology,Liaoning Universtity of Traditional Chinese Medicine,Shenyang 1166007) |
| Abstract: | Objective To study preparation technology of Fresh breath effervescent tablets. Methods The optimum molding technology was screened through single factor test such as disintegration time, quantity of producing foam, pH value and taste. Results The best preparation process was the optimum water extraction of Flos lonicerae and Hawthorn for 2 cycles, then inspissated and dried using lactose-mannitol （2 ： 1） and tea polyphenols, followed by pulveri zing. Citric acid-tartaric acid （1.5 ： 1） and sodium bicarbonate were used as effervescent material, sodium bicarbonate as admixture , and CMS-Na was added by two steps. The effervescent tablets had good taste, suitable hardness, good hydros copicity and valid disintegration time. Conclusion Our preparation procedure is stable and simple. |
| Keywords: | Fresh breath effervescent tablet test of single factor molding technology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |