灯盏花注射液对小鼠肠缺血再灌注肝损伤的保护作用

制作小鼠肠缺血再灌注肝损伤模型 ,观察灯盏花注射液对小鼠肠缺血再灌注肝损伤的保护作用。结果表明 ,小鼠肠系膜上动脉缺血 2 0 m in和再灌注 1h,血清丙氨酸转氨酶 (AL T)和谷胱甘肽 S-转移酶(GST)活性明显增高。不同剂量灯盏花注射液能降低肠缺血再灌注肝损伤小鼠血清 AL T和 GST的活性 ,明显改善肠缺血再灌注肝损伤小鼠的超氧化物歧化酶活性和丙二醛含量。病理检查结果也表明 ,灯盏花注射液对缺血再灌注肝损伤小鼠有一定的保护作用。提示灯盏花注射液对小鼠肠缺血再灌注肝损伤的保护作用与其抗氧化作用有关。

Protective effect oferigeron injections on hepatotoxicity induced by intestinal ischemia-reperfusion in mice

The liver injury was induced by intestinal ischemia reperfusion and the protective effect of erigeron injection (EI) was studied in mice. The results showed that serum alanine transaminase (ALT) and glutathione S transferase (GST) activity increased while the root of superior mesenteric artery was blocked with non injury artery clap for 20 minute and reperfusion for 1 hour. EI could protect the above changes induced by intestinal ischemia reperfusion. EI could reduce the activities of serum ALT and GST, decrease the content of hepatic MDA and significantly increase the activity of SOD. The pathological changes of hepatocytes induced by intestinal ischemia reperfusion were less in EI groups. These results suggested that EI could protect the liver of mice from injury induced by intestinal ischemia reperfusion. One of the mechanisms of hepatoprotective action was related to the antioxidative function of erigeron.