吉林省结核分枝杆菌对乙胺丁醇耐药状况分析

目的获得吉林省结核病乙胺丁醇耐药本底数据,评价现行结核病控制策略的效果。方法按照世界卫生组织/国际防痨和肺病联合会（WHO/IUATLD）的通行标准,采用分层整群抽样方法,获得覆盖全省各地区结核分枝杆菌,对其进行菌型鉴定及乙胺丁醇（EMB）药物敏感性测试。结果收集到临床分离的结核分枝杆菌菌株1 772株,EMB总体耐药率为6.83%;其中来自初治涂阳肺结核患者菌株为1 175株（66.14%）,EMB耐药率为4.34%;来自复治涂阳肺结核患者菌株597株（33.69%）,复治耐药率为11.73%。结论吉林省结核分枝杆菌EMB总体耐药情况较高,今后须进一步加强耐药结核病的防治及临床用药指导。

Analysis of ethambutol resistance in mycobacterium tuberculosis of Jilin province

Objective To apply international comparability of TB resistant to ethambutol information to evaluate the effect of the current TB control strategies. Methods According to WHO / IUATLD standards, sampling method using 100% of diagnostic centers for culture - positive isolates were separated bacterial type identification and ethambutol （EMB） drug susceptibility testing. Results 1 772 strains were collected and isolated for analysis of myeobacterium tuberculosis, etham- butol resistance rate was 16. 70% , which isolated from the smear positive TB patients the early of 1 175 （66. 14% ） , ethambutol resistance rate was 4. 34% ; 597 strains （33.69%） were isolated from retreatment smear-positive tuberculosis patients,the resistance rate of ethambutol was 11.73%. Conclusion Tuberculosis resistant to ethambutol of Jilin province is higher than that of national average level. It＇ s suggested to further strengthen the prevention and treatment of drug - re- sistant TB.