异体骨关节移植在胫骨上段骨肿瘤保肢治疗中的近期疗效

目的分析胫骨上段骨肿瘤患者接受同种异体骨父节移植的方法并评价该办法在胫骨七段保肢治疗中的近期疗效。方法1998年9月～2003年6月埘15例胫骨上段骨肿瘤患者行瘤段切除异体骨关节移植。其中男7例，女8例。年龄14～56岁。7例胫骨上段进展性骨巨细胞瘤．未接受化疗；8例胫骨上段恶性骨肿瘤，分别为骨肉瘤6例、梭形细胞肉瘤和恶性纤维组织细胞瘤各1例．均接受新辅助化疗．术前1～2个疗程、术后4～6个疗程。Enneking分期：IB期7例、ⅡA期2例、ⅡB期6例。所有患者采用广泛性边缘切除．移植异体骨关节长度6～16cm，平均12cm。结果术后所有患者均获随访3～58个月．平均27个月。接受化疗的8例胫骨上段恶性骨肿瘤无骨折，5例骨性愈合，3例骨不连，其中2例合并感染．局部复发1例，均行股骨下段截肢；Mankin评分：优2例，良2例，一般1例，差3例，优良率为50％。7例胫骨上段进展性骨巨细胞瘤，无感染和局部复发；2例骨小连．关节不稳2例，戴膝关节支具行走；Mankin评分：优3例，良2例，一般2例，优良率为71%。结论胫骨上段肄体骨父节移植有较高的许发症，但优势不可忽视，为胫骨上段进展性良性骨肿瘤和恶性骨肿瘤提供可选择的保肢治疗手段。

LIMB SALVAGE WITH OSTEOARTICULAR ALLOGRAFTS AFTER RESECTION OF PROXIMAL TIBIA BONE TUMORS

OBJECTIVE: To evaluate the short-term efficacy of osteoarticular allografts in the limb salvage of the proximal tibia. METHODS: From 1998 to 2003, 15 patients (7 males, 8 females; aged 14-56 yr. average 33) with bone tumor of the proximal tibia underwent osteoarticular allografts. among whom 7 had progressive giant cell tumor without any previous chemotherapy; 8 had malignant tumor with previous chemotherapy, including 6 patients with osteosarocoma, 1 with spindle cell sarcoma, and 1 with malignant fibrous histiocytoma. According to the Enneking system, the patients were classified into I B (7 patients), II A (2 patients), and II B (6 patients). All the patients underwent the marginal resection with an allograft (average length 12 cm, range 6-16 cm) implanted. RESULTS: The follow-up for an average of 21 months (range, 3-58 months) revealed that among the 8 patients with malignant tumor of the proximal tibia undergoing chemotherapy, 5 had union of the bone, 3 had no union of the bone; among the 3 patients, 2 had a complication of infection and 1 had a local recurrence. All the 3 patients underwent amputation at the lower part of the femur. According to the Mankin score, 2 patients had a perfect result, 2 good, 1 fair, and 3 poor, with a 50% effectiveness rate. Among the 7 patients with progressive giant cell tumor at the upper part of the tibia, none had infection or local recurrence, but 2 had nonunion of the bone and 2 had joint instability, aided by the knee-aiding system. According to the Mankin score, 3 patients had a perfect result, 2 good, and 2 fair, with a 71% effectiveness rate. CONCLUSION: The osteoarticular allograft of the proximal tibia has many advantages in spite of a relatively high rate of complications, and it is the limb salvage of choice for the progressive benign or malignant bone tumors of the proximal tibia.