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Primary vaginal clear cell adenocarcinoma accompanied by Herlyn-Werner-Wunderlich syndrome without prenatal diethylstilbestrol exposure: a case report |
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| Authors: | Ling Mei Juan Zou Qijun Chen Wei Jiang Yueyue Chen |
| Affiliation: | 1. Department of Gynecology, West China Second Hospital of Sichuan University, Chengdu 610041, Sichuan, China ; 2. Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second Hospital of Sichuan University, Chengdu 610041, Sichuan, China ; 3. Department of Pathology, West China Second Hospital of Sichuan University, Chengdu 610041, Sichuan, China |
| Abstract: | We report a rare case of a 40 years old woman with primary vaginal clear cell adenocarcinoma (CCA) accompanied by Herlyn-Werner-Wunderlich syndrome (HWWS) and without any prenatal diethylstilbestrol exposure. Pathological results indicated that the CCA was surrounded by adenosis and that there was a benign to malignant transformation of several glands in the epithelium, so the CCA was believed to have arisen from the adenosis. The literature review disclosed that genitourinary anomalies might be associated with an increased risk of adenocarcinoma, but the mechanism was not clear. |
| Keywords: | Clear cell adenocarcinoma (CCA) diethylstilbestrol genitourinary malformation Herlyn-Werner-Wunderlich syndrome vaginal adenosis |