Comparison of Corynebacterium Parvum With Freund's Complete Adjuvant as a Potentiator of the Immune Response To β-Human Chorionic Gonadotropin Linked to Tetanus Toxoid |
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| Authors: | DANA C. COVEY MD KENNETH A. LAURENCE |
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| Affiliation: | Department of Biological Sciences, University of Idaho, Moscow, Idaho |
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| Abstract: | ABSTRACT: Corynebacterium parvum was compared with Freund's complete adjuvant (FCA) for potentiation of the rabbit immune response to β-human chorionic gonadotropin linked to tetanus toxoid (β-hCG-TT). With each adjuvant, antibodies to hCG were detected using passive hemagglutination. Higher antibody titers were produced by FCA-treated animals. The ability of antisera to β-hCG-TT to neutralize the biological action of native hCG was determined by the rat uterine weight assay. Anti-β-hCG-TT sera from C. parvum-treated rabbits were not significantly different (p > 0.10) from FCA potentiated anti-β-hCG-TT sera in neutralizing hCG-induced uterine weight gain. C. parvum has potential for future application in active immunization studies of fertility regulation. |
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| Keywords: | Immunoreproduction female fertility regulation adjuvants immunity |
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