Hemodynamic Effects at Rest and during Exercise in Long-term Treatment with Prazosin in Chronic Congestive Heart Failure |
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| Authors: | ARNE WESTHEIM ARNE KOSS EGIL SIVERTSSEN |
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| Affiliation: | Department of Internal Medicine, Division of Cardiology, and Laboratory of Clinical Physiology, Ullevaal Hospital, University of Oslo, Oslo, Norway |
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| Abstract: | ABSTRACT. The long-term effects of prazosin in chronic congestive heart failure were studied in 10 patients (New York Heart Association class III-IV) in a double-blind cross-over study. Patients with systolic blood pressure > 120 mmHg and left ventricular filling pressure > 15 mmHg were included. Prazosin lowered the arteriovenous oxygen difference both at rest and during exercise (p < 0.05), increased cardiac index (p < 0.01) and reduced right atrial pressure and systemic vascular resistance (p < 0.05) during exercise. Left ventricular filling pressure was also reduced, but not significantly, during exercise. Our data show that prazosin has beneficial long-term effects during exercise in patients with chronic congestive heart failure. |
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| Keywords: | congestive heart failure exercise hemodynamics prazosin |
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