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| 皂角皂苷元化学成分研究 | |
| 引用本文： | 陈晓岚,屈凌波,韩维诚,王继扬. 皂角皂苷元化学成分研究[J]. 中草药, 2001, 32(3): 195-197 |
| 作者姓名： | 陈晓岚 屈凌波 韩维诚 王继扬 |
| 作者单位： | 1. 河南医科大学基础医学院，河南郑州 450052 2. 郑州大学应用化学重点实验室，河南郑州 450052 3. 山东大学晶体重点实验室，山东济南 340040 |
| 基金项目： | 山东大学晶体重点实验室和河南省自然科学基金资助项目 |
| 摘 要： | 目的：研究皂角皂苷元的化学结构。方法：通过提取、完全水解、层析等方法，从皂角中获得2种皂苷元，制备系列衍生物并进行红外、核磁共振、质谱和晶体衍射等分析。结果：2种皂有皂苷元分别为3－羟基－12－齐墩果烯－28－酸和3，16－二羟基－12－齐墩果烯－28－酸。结论：首次确定了2种皂角皂苷元的化学结构和晶体结构。 |
| 关 键 词： | 皂角 3－羟基－12－齐墩果烯－28－酸 3 16－二羟基－12－齐墩果烯－28－酸 皂苷元 中药 |
| 文章编号： | 0253-2670(2001)03-0195-03 |
| 收稿时间： | 2000-02-25 |
| 修稿时间： | 2000-02-25 |
Studies on structure of sapogenins from pod of Gleditsia sinensis |
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| CHEN Xiao lan,QU Ling bo,HAN Wei cheng and WANG Ji yang. Studies on structure of sapogenins from pod of Gleditsia sinensis[J]. Chinese Traditional and Herbal Drugs, 2001, 32(3): 195-197 | |
| Authors: | CHEN Xiao lan QU Ling bo HAN Wei cheng WANG Ji yang |
| Affiliation: | CHEN Xiao lan 1,QU Ling bo 2,HAN Wei cheng 2,WANG Ji yang 3 |
| Abstract: | Object To study on the structure of sapogenins from pod of Gleditsia sinensis Lam Methods Pod of G. sinensis was extracted with solvents and the constituents in the extraction isolated, after hydrolised completely, with the aid of flash chromatography to obtain 2 gledgenins Results The structures of the 2 gledgenins were proved to be 3 hydroxy 12 oleanen 28 oic acid and 3, 16 dihydroxy 12 oleanen 28 oic acid respectively as shown by IR, NMR, MS and crystallographic data The structures were further verified by acylation, methylation and followed by reaction with 3, 5 dinitro benzoyl chloride Conclusion New crystalline derivatives were obtained to provide further evidence of their structures |
| Keywords: | pod of Gleditsia sinensis Lam 3 hydroxy 12 oleanen 28 oic acid 3 16 dihydroxy 12 oleanen 28 oic acid |
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