| 被动型Heymann肾炎大鼠肾小球基底膜电荷屏障的变化 |
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| 引用本文： | 陈书芬,阴东平,张建民,尹克铮,万美玲. 被动型Heymann肾炎大鼠肾小球基底膜电荷屏障的变化[J]. 东南大学学报(医学版), 1996, 0(4) |
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| 作者姓名： | 陈书芬 阴东平 张建民 尹克铮 万美玲 |
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| 作者单位： | 南京医科大学附属南京第一医院肾内科，南京铁道医学院附属医院 |
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| 摘 要： | 目的：检测被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）肾小球基底膜电荷屏障的变化。方法：将含肾小管抗体的抗血清腹腔注射于大鼠体内建立被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）模型。用聚乙烯亚胺作为示踪剂，在电镜下观察ＰＨＮ大鼠肾小球基底膜阴离子位点的变化。结果：ＰＨＮ大鼠肾小球基底膜阴离子位点明显减少。结论：在ＰＨＮ中，电荷屏障的破坏是发生蛋白尿的一个原因
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| 关 键 词： | 被动型Heymann肾炎；肾小球基底膜；电荷屏障；聚乙烯亚胺 |
The Changes in Anionic Sites in Glomerular Basement Membrane in Passive Heymann Nephritic Rats |
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| Chen Shufen. The Changes in Anionic Sites in Glomerular Basement Membrane in Passive Heymann Nephritic Rats[J]. Journal of Southeast Univ: Medical Sci Ed, 1996, 0(4) |
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| Authors: | Chen Shufen |
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| Abstract: | Objective :To investigate the glomerular charge barrier change in passive heymann nephritic(PHN) rats.Method :Polyethyleneimine(PEI) was used as tracing marker to observe the anionic sites in glomerular basement membrane(GBM) by electronmicroscope.Result :Anionic sites in GBM of PHN rats were fewer than those of normal rats.Conclusion :There may be a glomerular charge barrier damage in PHN that causes proteinuria. |
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| Keywords: | passive heymann nephritis glomerular basement membrane charge barrier polyethyleneimine(PEI) |
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