| 脂多糖激活大鼠库普细胞产生的递质对肝细胞损害的影响 |
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| 引用本文： | 冯俊明,史景泉,刘友生,殷育松. 脂多糖激活大鼠库普细胞产生的递质对肝细胞损害的影响[J]. 中华消化外科杂志, 2003, 2(1): 16-19 |
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| 作者姓名： | 冯俊明 史景泉 刘友生 殷育松 |
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| 作者单位： | 400038,第三军医大学西南医院病理学研究所 |
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| 基金项目： | 国家自然科学基金资助项目 (No .3 9770 75 9) |
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| 摘 要： | 目的 探讨库普细胞 (KC)产生的活性递质对肝细胞的损害作用。方法 将脂多糖(LPS)刺激KC后产生的活性递质加入同时培养的肝细胞中 ,并观察肝细胞肝功能的变化。结果 KC上清中TNFα、IL - 6和NO的浓度增高的同时 ,培养肝细胞GOT和GPT增高 ,同时ALB降低。结论 LPS刺激KC后产生的活性递质能明显损伤肝细胞
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| 关 键 词： | 脂多糖 肝功能 肿瘤坏死因子α 白介素6 一氧化氮 |
| 文章编号： | 1671-4555(2003)01-0016-04 |
| 修稿时间： | 2002-09-23 |
The effects of the mediators produced by Kupffer cells induced by LPS on the injury of rat hepatocytes |
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| Feng Junming,Shi Jingquan,Liu Yousheng,Yin Yusong. Research Institute of Pathology,Southwest Hospital,Third Military Medical University,Chongqing. The effects of the mediators produced by Kupffer cells induced by LPS on the injury of rat hepatocytes[J]. Chinese Journal of Digestive Surgery, 2003, 2(1): 16-19 |
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| Authors: | Feng Junming Shi Jingquan Liu Yousheng Yin Yusong. Research Institute of Pathology Southwest Hospital Third Military Medical University Chongqing |
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| Affiliation: | Feng Junming,Shi Jingquan,Liu Yousheng,Yin Yusong. Research Institute of Pathology,Southwest Hospital,Third Military Medical University,Chongqing 400038 |
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| Abstract: | |
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| Keywords: | LPShepatocellular function TNF interleukin 6 NO |
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