| 大叶香茶菜抗肿瘤成分大叶庚的研究(Ⅱ) |
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| 引用本文： | 程培元,许美娟,林永乐,石金城. 大叶香茶菜抗肿瘤成分大叶庚的研究(Ⅱ)[J]. 药学学报, 1982, 17(12): 917-921 |
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| 作者姓名： | 程培元 许美娟 林永乐 石金城 |
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| 作者单位： | 南京药物研究所(程培元，许美娟，林永乐)，南京药物研究所(石金城) |
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| 摘 要： | 鉴定了从大叶香茶菜Rabdosia macrophylla中分得的另外四种成分。三种为已知成分乌苏酸,香茶菜甲素(AmethystoidinA)及Enmenol。另一大叶庚为新的B-seco-ent-kaurene二萜,命名为RabdophyllinG,能延长荷艾氏腹永癌小鼠的生命并能抑制体外肝癌细胞的生长。
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| 关 键 词： | 大叶香茶菜 大叶香茶菜庚 香茶菜甲素 Enmenol 乌苏酸 |
| 收稿时间： | 1981-08-17 |
THE STRUCTURE OF RABDOPHYLLIN G,AN ANTITUMOR CONSTITUENT OF RABDOSIA MACROPHYLLA (Ⅱ) |
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| CHENG Pei-yuan,XU Mei-juan,LIN Yong-le and SHI Jin-cheng. THE STRUCTURE OF RABDOPHYLLIN G,AN ANTITUMOR CONSTITUENT OF RABDOSIA MACROPHYLLA (Ⅱ)[J]. Acta pharmaceutica Sinica, 1982, 17(12): 917-921 |
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| Authors: | CHENG Pei-yuan XU Mei-juan LIN Yong-le SHI Jin-cheng |
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| Affiliation: | Nanjing Institute of Materia Medica |
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| Abstract: | The identification of four components of Rabdosia macrophylla was accomplished, three of them were shown to be identical with the known Amethystoidin A, ursolic acid and Enmenol. The 4th. is a new B-seco-ent-kaurene diterpenoid, to which the name Rabdophyllin G is suggested. Spectroscopic investigation and chemical conversion into dihydroisodonal (Ⅲ) and dihydroisodonal derivative (Ⅳ) established the structure of Rabdophyllin G. It exhibited significant inhibitory action against Ehrlich ascites carcinoma in mice. |
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| Keywords: | Rabdosia macrophylla Rabdophyllin G Amethystoidin A Enmenol Ursolic acid |
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