坦索罗辛联合五淋化石丸在输尿管下段结石体外震波碎石术后辅助排石效果观察

目的探讨体外震波碎石术(ESWL)治疗输尿管下段结石后应用坦索罗辛联合五淋化石丸辅助排石的效果。方法对120例输尿管下段结石患者随机分为对照组(60例)和治疗组(60例),对照组ES-WL后应用五淋化石丸,1.25g/次,3次/d,未应用输尿管平滑肌松弛剂;治疗组ESWL后在对照组治疗方案的基础上予以口服α_1肾上腺索能受体阻滞剂坦索罗辛,0.4 mg/次,1次/d。观察两组的结石排出率、结石排出时间、并发症(肾绞痛、发热、血尿)发生率及药物的副作用并比较。每例患者观察时间不超过2周。结果治疗组排石率为88.3%,对照组为46.7%,治疗组高于对照组(P0.01)。肾绞痛、发热、血尿的发生率对照组分别为35.0%、20.0%、23.3%,治疗组分别为10.0%、6.7%、8.3%,治疗组低于对照组(P0.05)。治疗组除2例发生头晕外,无其他不良反应发生。结论坦索罗辛联合五淋化石丸能够发挥两者的协同作用,提高输尿管下段结石ESWL后的排石率,降低肾绞痛、发热、血尿及药物副作用的发生率,且安全有效,值得临床推广应用。

Assisted effect of discharging stone of tamsulosin combined with wulinhuashi pill after the extracorporeal shock wave lithotripsy of lower ureteral stone

Objective To study the assisted effect of discharging stone of tamsulosin combined with wulinhuashi pill after the extracorporeal shock wave lithotripsy(ESWL)of lower ureteral stone.Methods One hundred and twenty patients with lower ureteral stone were randomly divided into the control group(n=60)and the treatment group(n=60).After ESWL,the control group used wulinhuashi pill,the dose was 1.25 g three times daily,not used ureteral smooth muscle relaxation agent.After ESWL,on the base of treatment of the control group the treatment group used a,adrenaline receptor blocker tamsulosin,the dose was 0.4 mg daily as a single dose.The rate of discharging, the time of discharging stone and the complications renal colic,fever,hematuria,side effects of the drug were observed.The observation time of each patient wasn’ t more than two weeks.Results The rate of the discharging stone of the treatment group was 88.3%.The rate of discharging stone of the control group was 46.7%.The rate of the treatment group was higher than that of the control group(P<0.01).The control group’ s incidence of renal colic,fever and hematuria were 35.0%,20.0%,23.3%,respectively.Those of the treatment group were 10.0%,6.7%,8.3%.those of the treatment group were lower than those of the control group(P<0.05).In the treatment group there was no other adverse reaction except the dizziness occurred in two cases.Conclusion The combining of the both tamsulosin and wulinhuashi pill can have a synergic effect,improve the rate of discharging stone after ESWL and shorten the time of discharging stone.The incidence of renal colic,fever,hematuria and the side effects of drug are low.It is safe and effective method,and worth clinical application.