复方肺心安片对肺心病肺动脉高压大鼠NO和AngⅡ的影响

目的:观察复方肺心安片对肺心病肺动脉高压大鼠NO和AngII的影响。方法:以2%野百合碱按60mg/kg一次性腹腔注射,复制大鼠肺心病肺动脉高压模型。观察中药复方肺心安片对大鼠血中一氧化氮(NO)和血管紧张素(AngⅡ)的影响。结果:复方肺心安片能明显提高血中NO浓度,降低血中AngⅡ的含量。结论:复方肺心安片通过提高血中NO,降低AngⅡ浓度,舒张肺动脉抑制血管平滑肌细胞的增生,从而降低肺动脉高压,阻断肺心病发展的关键环节。

The Influence of Fei-xin-an Tablets on the Expressions of NO and AngⅡ in Cor Pulmonale Rats with Pulmonary Hypertension

Objective:To observe the milittion of Fei-xin-an Tablets against the NO and AngII in the blood of Rat.Methods:To copy the rat’s model of cor pulmonale by injecting the abdominal cavity of rat disposably with two percentages of MCT(60mg/kg),observing the militation of feixinan tablets against the NO and AngⅡ in the blood of rat.Results:The Observation shows that Feixinan tablet can increase the concentration of NO and decrease the concentration of AngⅡ in the blood of rat.Conclusion:Feixinan tablet decrease the high pressure of lung artery and prevent the key tache of the development of cor pulmonale by increasing the concentration of NO and decreasing the concentration of AngⅡ in blood and expanding the lung artery as well as containing the generation and growth of cell of smooth muscle in blood vessel.