Early and Delayed Effects of Hypoxia during the Infantile Period on Behavioral and Hormonal Reactions of Rats |
| |
| Authors: | V. A. Mikhailenko I. P. Butkevich T. R. Bagaeva G. V. Makukhina V. A. Otellin |
| |
| Affiliation: | (1) Department of Animal Physiology, Center for Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands;(2) Institute for Zoology, University of Regensburg, Universitaetsstr. 31, 93053 Regensburg, Germany;(3) Department of Psychiatry, Groningen University Hospital, Groningen, The Netherlands;(4) Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden, The Netherlands |
| |
| Abstract: | We studied the early and delayed effects of hypoxia during the infantile period on the behavioral reactions and corticosterone concentration in male rats. The elevation of corticosterone concentration, decrease in the immobility time (forced swimming test), and increase in the nociceptive response (formalin test) were observed in 7-day-old rats immediately after hypoxia. Adult animals exposed to hypoxia at the age of 7 days exhibited elevated basal corticosterone level and lengthened immobility time. Hypoxia had the same effect on plasma corticosterone concentration in 7-day-old and adult rats. Changes in corticosterone concentration after forced swimming were shown to differ in hypoxic animals and non-hypoxic specimens. Studying the dynamics of age-related variations in the test parameters will contribute to the understanding of pathogenetic mechanisms and development of new methods for pharmacological correction of postnatal changes in CNS after hypoxia during early ontogeny. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
