| 蒺藜总皂苷对AD大鼠GSK-3β的影响 |
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| 引用本文： | 彭胜国,甘云波.蒺藜总皂苷对AD大鼠GSK-3β的影响[J].咸宁医学院学报,2010,24(3):189-191. |
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| 作者姓名： | 彭胜国 甘云波 |
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| 作者单位： | [1]武汉大学基础医学院,湖北武汉430071 [2]咸宁学院基础医学院,湖北武汉430071 |
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| 摘 要： | 目的探讨蒺藜总皂苷对AD大鼠GSK-3β的影响。方法采用AlCl3灌胃制作AD大鼠模型,Morris水迷宫检测大鼠空间记忆能力,免疫印迹检测GSK-3β蛋白水平。结果蒺藜总皂苷明显缩短大鼠寻找平台的时间,降低GSK-3β蛋白水平。结论蒺藜总皂苷能有效改善因AlCl3所致的大鼠空间记忆障碍,其机制可能与抑制GSK-3β蛋白过度激活有关。
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| 关 键 词： | 蒺藜总皂苷 阿尔茨海默病 空间记忆 GSK-3β |
Effect of Gross Saponin from Tribulus Terrestris L on Alzheimer's Disease Rats |
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| PENG Sheng-guo,Gan Yun-bo.Effect of Gross Saponin from Tribulus Terrestris L on Alzheimer's Disease Rats[J].Journal of Xianning Medical College,2010,24(3):189-191. |
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| Authors: | PENG Sheng-guo Gan Yun-bo |
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| Institution: | (Wuhan University Basic Medical School,Wuhan Hubei 430071,China) |
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| Abstract: | Objective To investigate the effect of gross saponin from Tribulus terrestris L（GSTT） on Alzheimer＇s disease（AD） rats.Method The AD model was established by AlCl3.Spatial memory retention and the expression of GSK-3β protein were detected by Morris and Western blot,respectively.Results It was shown that the escape latency was increased significantly after AlCl3 injection in Morris maze,and GSTT could markedly shorten AlCl3-induced the increase of escape latency,decrease the expression of GSK-3β protein.Conclusion These results suggest that GSTT can effectively prevent the rats from AlCl3-induced spatial memory deficits by inhibiting GSK-3β overactivation. |
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| Keywords: | gross saponin from Tribulus terrestris L（GSTT） Alzheimer＇s disease（AD） Spatial memory GSK-3β |
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