Dyskeratosis congenita associated with three malignancies |
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Authors: | C Baykal † A Kavak ‡ P Gülcan § N Büyükbabani¶ |
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Institution: | Istanbul University, Istanbul Medical School, Department of Dermatology Istanbul, Turkey. baykalc@istanbul.edu.tr |
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Abstract: | Dyskeratosis congenita is a rare inheritable disorder characterized by abnormalities of the skin, nails and oral mucosa. Aplastic anaemia resulting from bone marrow hypoplasia is a frequent cause of death. Squamous cell carcinoma developing from leukoplakia and visceral malignancies are other complications of the disease. We report here a case of dyskeratosis congenita in a man who developed three neoplasias of different systems over a period of many years. Squamous cell carcinoma and gastric adenocarcinoma manifested 17 years after the man was diagnosed with Hodgkin's disease. |
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Keywords: | dyskeratosis congenita malignancy Hodgkin's disease squamous cell carcinoma gastric adenocarcinoma |
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