胸腺瘤患者血清sFas水平与重症肌无力相关性研究

目的 检测胸腺瘤患者血清可溶性Fas(sFas)水平,探讨重症肌无力(Myasthenia Gravis,MG)的发病机制.方法 将131例胸腺瘤患者根据是否合并MG分成A B两组,A组70例,B组61例,应用ELISA法检测血清sFas水平.对两组结果 进行统计分析.结果 两组间比较,A组患者血清sFas水平明显高于B组,差异极显著(P<0.001);两组间同分型同分期胸腺瘤间sFas差异极显著(P<0.001);同组间无论胸腺瘤分型或分期是否相同sFas水平无统计学差异(P＞0.05);单纯眼肌型MG患者血清sFas明显低于其他临床分型MG(P<0.001).结论 胸腺瘤的生物学特性与MG的发生无直接相关性,Fas 基因和蛋白结构的变异可能是MG发生的直接原因,通过进一步研究,血清sFas水平可能作为评价病情和疗效的客观指标.

The Study on Serum sFas Levels and Myasthenia Gravis in Patients with Thymoma

Objective To detect the expression of serum soluble Fas（sFas） in patients with thymoma,and to investigate the pathogenesis of myasthenia gravis（MG）.Methods According to being associated with MG or not,131 patients with thymoma were divided into two groups：70 cases in Group A,61 cases in Group B.The expression of serum sFas was detected by ELISA,and the results of both groups were subjected to statistical analysis using t test.Results The expression level of sFas in Group A was significantly higher than that in Group B（P〈0.001）,and there was a statistical difference between patients with the same type and stage in both Group A and Group B（P〈0.001）.However,the results showed no statistical difference in the same group whether the patients were with identical types,stage or not.Furthermore,an apparent expression decrease of sFas was manifested in simple ocular MG patients compared to other clinical types（P〈0.001）.Conclusions The characteristics of thymoma were not correlated with MG.The mutation of Fas gene and protein may result in the development of MG,and to further study, serum sFas may be provided as an indicator of disease assessment and curative effect.