己酮可可碱对高压电烧伤病人创面微循环的影响

目的 探讨己酮可可碱(PTX)对高压电烧伤病人创面微循环的影响,观察其临床疗效.方法 对已经明确诊断的高压电烧伤病人58例,其中男32例,女26例,平均年龄32.12±10.34岁,随机分为常规治疗组(对照组)和PTX治疗组(治疗组),每组29例.治疗组给予PTX(每次0.1g静点,每日一次,共7d)治疗,其余治疗两组均一致.用激光多普勒微循环图像仪检测2组病人入院时治疗前及治疗后24h、48h、3d、5d、7d后六个时相创面微循环血液灌流值(MPD),对观测结果 进行对比分析.结果 两组组间比较:治疗前创面MPD分别是(1.2±0.38)V、(1.36±0.33)V,无显著性差异(P＞ 0.05);治疗后各时相创面MPD值比较,有显著性差异(P＜0.05),治疗组创面血运明显优于对照组创面血运.结论 PTX 对高压电烧伤病人创面微循环有改善作用.

Effects of Pentoxifylline on the High Voltage Electric Burn Wound Microcirculation in Patients

Objective To study effects of pentoxifylline drugs on high voltage electric burn wound microcirculation of patients and to observe the clinical efficacy.Methods 58 cases of high-voltage burn patients with a clear diagnosis,including 32 males and 26 females,mean age 32.12 ± 10.34 years old,were randomly divided into conventional treatment group（control group） and effects of pentoxifylline treatment group（treatment group）,each group of 29 cases.The treatment group received treatment of pentoxifylline（0.1 g each static point,once a day,7 days）,the remaining treatment were consistent in two groups.Microcirculation with laser Doppler image detected two groups of patients on admission before treatment and after 24h,48h,3d,5d,7d after the six-phase wound microcirculation of blood perfusion values（MPD）,a comparative analysis of the observations.Results Comparison between the two groups：pre-treatment wound MPD were （1.2±0.38）V,（1.36±0.33）V, with no significant difference,P 〉 0.05,and between the two groups after treatment phase wound MPD value comparison with a significant difference,P 〈 0.05.Conclusion Pentoxifylline drugs improved the microcirculation of patients with high voltage electrical injury wound.