| 盐酸米诺环素膜剂的制备与质量控制 |
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| 引用本文： | 侯昌元,李红玉.盐酸米诺环素膜剂的制备与质量控制[J].中国药师,2011,14(6):821-823. |
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| 作者姓名： | 侯昌元 李红玉 |
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| 作者单位： | 辽宁医学院药学院,辽宁锦州,121001 |
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| 摘 要： | 目的:制备盐酸米诺环素膜剂并制定该制剂的质量控制方法。方法:以聚乙烯醇（PVA 17-88）;羧甲基纤维素钠（CMC-Na）为成膜材料,制备盐酸米诺环素膜剂,采用高效液相色谱法进行含量测定,测定波长为280nm。结果:盐酸米诺环素浓度测定的线性范围为0.1～2.0mg·ml-1,r=0.9999（n=7）,平均回收率为98.88%,RSD为0.88%。结论:该膜剂制备工艺可行,含量测定方法准确快速。
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| 关 键 词： | 盐酸米诺环素 膜剂 质量控制 |
Preparation and Quality Control of Minocycline Hydrochloride Film |
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| Hou Changyuan,Li Hongyu.Preparation and Quality Control of Minocycline Hydrochloride Film[J].China Pharmacist,2011,14(6):821-823. |
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| Authors: | Hou Changyuan Li Hongyu |
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| Institution: | Hou Changyuan,Li Hongyu(School of Parmacy,Liaoning Medical University,Liaoning Jinzhou,121001,China) |
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| Abstract: | Objective： To investigate the method for preparation and quality control of minocycline hydrochloride film. Method： Minocycline hydrochloride film was prepared with polyvinyl alcohol （PVA 17-88 ） and sodium carboxymethyl cellulose （CMC-Na） as the adjuvants. The content determination was established by HPLC at wavelength of 280 nm. Result： The linear range of minocycline hydrochloride was 0. 1-2.0 mg·ml^-1 （r =0. 999 9,n =7）, and the average recovery was 98.88 % （RSD =0. 88% ）. Conclusion： The preparation technique of the film was reasonable and the content determination was precise, quick and reliable. |
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| Keywords: | Minocycline hydrochloride Film Quality control |
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