| 散发性乳癌WIF-1基因启动子区多态性研究 |
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| 引用本文： | 王盛楠,侯琳,韩琳琳,葛银林. 散发性乳癌WIF-1基因启动子区多态性研究[J]. 齐鲁医学杂志, 2011, 26(4): 290-292,294 |
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| 作者姓名： | 王盛楠 侯琳 韩琳琳 葛银林 |
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| 作者单位： | 青岛大学医学院生物化学与分子生物学教研室,山东青岛,266021 |
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| 基金项目： | 青岛市公共领域科技支撑计划项目，山东省自然科学基金资助项目，山东省高等学校科技计划项目 |
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| 摘 要： | 目的 探讨WIF-1基因启动子区rs58172684 A/G与rs2336433 C/T位点单核苷酸多态性与散发性乳癌发生的关系.方法 采用等位基因特异性扩增(ASA)法对200例乳癌病人和200例正常对照者的WIF-1基因启动子区rs58172684 A/G与rs2336433 C/T位点单核苷酸多态性进行分析,PC...
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| 关 键 词： | 乳腺肿瘤 基因,WIF-1 多太性,单核苷酸 |
POLYMORPHISM OF WIF-1 GENE PROMOTER IN SPORADIC BREAST CANCER |
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| WANG SHENG-NAN,HOULIN,HAN LIN-LIN,GE YIN-LIN. POLYMORPHISM OF WIF-1 GENE PROMOTER IN SPORADIC BREAST CANCER[J]. Medical Journal of Qilu, 2011, 26(4): 290-292,294 |
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| Authors: | WANG SHENG-NAN HOULIN HAN LIN-LIN GE YIN-LIN |
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| Affiliation: | WANG SHENG-NAN,HOU LIN,HAN LIN-LIN,GE YIN-LIN(Department of Biochemistry and Molecular Biology,Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To investigate the relationship between a single nucleotide polymorphism of WIF-1 gene promoter rs58172684 A/G and rs2336433 C/T site,and the occurrence of sporadic breast cancer. Methods Allele specific amplification(ASA) was used to analyze the single nucleotide polymorphism of WIF-1 gene promoter rs58172684 A/G and rs2336433 C/T site among 200 cases of sporadic breast cancer and 200 samples of normal controls,and the PCR products were sequenced. ResultsThe frequency of WIF-1 gene promoter genot... |
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| Keywords: | breast neoplasms gene WIF-1 polymorphism single nucleotide |
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