| 左卡尼汀联合促红细胞生成素治疗肾性贫血临床观察 |
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| 引用本文： | 车华,苏东东,赵文琪. 左卡尼汀联合促红细胞生成素治疗肾性贫血临床观察[J]. 中国药师, 2011, 14(7): 1023-1024 |
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| 作者姓名： | 车华 苏东东 赵文琪 |
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| 作者单位： | 广州军区武汉总医院血液净化科,武汉,430070 |
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| 摘 要： | 目的：探讨左卡尼汀联合促红细胞生成素治疗肾性贫血的临床疗效。方法：56例血液透析（hemodialysis，HD）伴有肾性贫血的尿毒症患者随机分为治疗组与对照组，每组28例。全部患者均应用促红细胞生成素（EPO）4000u，皮下注射，每周2次。治疗组于HD结束后静脉注射左卡尼汀1．0g，每周2次，疗程12周。所有患者分别记录治疗前和治疗开始后12周的血红蛋白、红细胞压积、C-反应蛋白。结果：两组患者经治疗后，贫血指标均得以改善，但治疗组升高的幅度更明显（P〈0．05），炎症指标CRP水平均较治疗前下降，但治疗组下降的幅度更明显（P〈0．05）。治疗组总有效率达到92．85％，亦明显高于对照组（P〈0．05）。治疗组2例患者出现轻度恶心。结论：左卡尼汀可加强EPO的疗效。左卡尼汀联合EPO治疗肾性贫血安全有效。
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| 关 键 词： | 左卡尼汀 促红细胞生成素 肾性贫血 |
Clinic Observation of L-carnitine Combined with Erythropoietin in the Treatment of Renal Anemia |
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| Che Hua,Su Dongdong,Zhao Wenqi. Clinic Observation of L-carnitine Combined with Erythropoietin in the Treatment of Renal Anemia[J]. China Pharmacist, 2011, 14(7): 1023-1024 |
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| Authors: | Che Hua Su Dongdong Zhao Wenqi |
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| Affiliation: | Che Hua,Su Dongdong,Zhao Wenqi(Department of Blood Purification,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China) |
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| Abstract: | Objective:To investigate the therapeutic effect of L-carnitine combined with erythropoietin in hemodialysis patients with renal anemia.Method:56 renal anemic patients were randomly divided into the treatment group(TG)and control group(28 cases for each).1.0 g L-carnitine injection was intravenously dropped twice a week for the TG patients during the dialysis.All the patients were treated with erythropoietin and observed for 12 weeks.The changes in Hb,HCT and serum C-reactive protein(CRP)levels and side effe... |
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| Keywords: | L-camitine Erythropoietin Renal anemia |
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