| 沙利度胺对人肝癌细胞株SMMC-7721荷瘤鼠移植瘤作用 |
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| 引用本文： | 李军霞,孙萍,孙等军,董亮亮,夏玉军.沙利度胺对人肝癌细胞株SMMC-7721荷瘤鼠移植瘤作用[J].齐鲁医学杂志,2011,26(5):402-404. |
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| 作者姓名： | 李军霞 孙萍 孙等军 董亮亮 夏玉军 |
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| 作者单位： | 1. 青岛大学医学院附属烟台毓璜顶医院肿瘤科,山东烟台,264000
2. 青岛大学医学院人体解剖学教研室 |
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| 摘 要： | 目的 研究沙利度胺对人肝癌细胞株SMMG7721荷瘤鼠移植瘤的生长抑制作用及可能机制.方法 建立肝癌细胞株SMMC-7721的荷瘤鼠模型,观察沙利度胺组与对照组瘤体变化,应用免疫组化方法测定瘤体组织中微血管密度,ELISA法测定荷瘤鼠外周血血管内皮生长因子(VEGF)表达,并采用流式细胞仪测定瘤体组织细胞凋亡指数及瘤...
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| 关 键 词： | 沙利度胺 肝肿瘤 细胞凋亡 血管内皮生长因子A |
EFFECT OF THALIDOMIDE ON HEPATOCYTE CELL LINE SMMC-7721 HUMAN LIVER CANCER MODEL IN MICE |
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| LI JUN-XIA,SUN PING,SUN DENG-JUN,DONG LIANG-LIANG,XIA YU-JUN.EFFECT OF THALIDOMIDE ON HEPATOCYTE CELL LINE SMMC-7721 HUMAN LIVER CANCER MODEL IN MICE[J].Medical Journal of Qilu,2011,26(5):402-404. |
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| Authors: | LI JUN-XIA SUN PING SUN DENG-JUN DONG LIANG-LIANG XIA YU-JUN |
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| Institution: | LI JUN-XIA,SUN PING,SUN DENG-JUN,DONG LIANG-LIANG,XIA YU-JUN (Department of Oncology,The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College,Yantai 264000,China) |
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| Abstract: | ObjectiveTo investigate the inhibitory action of thalidomide on transplanted human hepatoma cell line SMMC-7721 in mice and its possible mechanism.MethodsA mouse model bearing liver cancer cell line SMMC-7721 was created.Tumor volume in thalidomide group and control group was observed.Microvessel density(MVD) of tumor was detected byusing immunohistochemistry;VEGF protein levels by ELSIA;index of apoptosis and expression of Caspase-3 were determined by flow cytometry.ResultsA model of bearing liver cancer c... |
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| Keywords: | thalidomide liver neoplasms apoptosis vascular endothelial growth factor A |
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