| 肾移植术后患者全血西罗莫司浓度监测结果分析 |
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| 引用本文： | 熊樱,吴笑春,李罄,余爱荣,熊磊,郭珩,辛华雯.肾移植术后患者全血西罗莫司浓度监测结果分析[J].中国药师,2011,14(7):941-944. |
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| 作者姓名： | 熊樱 吴笑春 李罄 余爱荣 熊磊 郭珩 辛华雯 |
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| 作者单位： | 广州军区武汉总医院临床药理科,武汉,430070 |
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| 摘 要： | 目的:探讨肾移植术后患者全血西罗莫司浓度的治疗窗以及西罗莫司对血常规、肝肾功能、血脂和尿蛋白的影响。方法:采用微粒子发光免疫分析技术（MEIA）测全血西罗莫司谷浓度。对3年来294例次肾移植术后患者全血西罗莫司浓度,以及西罗莫司对血常规、肝肾功能、血脂和尿蛋白的影响进行分析。结果:294例次全血西罗莫司浓度中有206例次（70%）在3～8ng·ml-1范围内。肾移植6个月后,全血西罗莫司浓度测定值随移植时间延长而降低。服用西罗莫司后的尿蛋白数值升高,与服用之前相比差异有统计学意义（P<0.05或0.01）。结论:全血西罗莫司谷浓度治疗窗:术后1～3个月为4～6ng·ml-1,第4～6个月为3～6ng·ml-1,>6个月为3～5ng·ml-1。
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| 关 键 词： | 肾移植术后 西罗莫司 血药浓度 肝肾功能 尿蛋白 |
Monitoring Analysis of Whole Blood Sirolimus Concentrations in Renal Transplant Patients |
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| Xiong Ying,Wu Xiaochun,Li Qin,Yu Airong,Xiong Lei,Guo Heng,Xin Huawen.Monitoring Analysis of Whole Blood Sirolimus Concentrations in Renal Transplant Patients[J].China Pharmacist,2011,14(7):941-944. |
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| Authors: | Xiong Ying Wu Xiaochun Li Qin Yu Airong Xiong Lei Guo Heng Xin Huawen |
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| Institution: | Xiong Ying,Wu Xiaochun,Li Qin,Yu Airong,Xiong Lei,Guo Heng,Xin Huawen(Department of Clinical Pharmacology,Wuhan General Hospital of Guangzhou Military Command,PLA,Wuhan 430070,China) |
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| Abstract: | Objective:To investigate the therapeutic window of sirolimus and its effects on blood routine,urine protein,blood lipids, liver and renal function of renal transplant patients.Method:The whole blood sirolimus concentrations of 294 cases of renal transplant patients in 3 years were determined by microparticle enzyme immunoassay(MEIA).The effects of sirolimus on blood routine,urine protein, blood lipids,liver and renal function were also studied.Result:The blood sirolimus concentrations of 206 cases were with... |
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| Keywords: | Renal transplantation Sirolimus Blood concentrations Liver and renal function Urine protein |
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